Poly (ADP-ribose) polymerase



Poly (ADP-ribose) polymerase (PARP) is involved in DNA repair and programmed cell death. The PARP family contains 17 members. PARP is composed of 4 domains. Among them are DNA-binding domain which contains 2 zinc fingers and catalytic domain. Tankyrase (Tank) is a PARP which contains ankyrin repeats (a 33-residue repeat with 2 α-helices separated by loops). The images at the left and at the right correspond to one representative PARP, i.e. the NMR structure of human Poly (ADP-ribose) polymerase (2dmj).

PARP 1
3od8, 3oda – hPARP 1 zinc finger 1 + DNA – human

2dmj, 1v9x - hPARP 1 zinc finger 1 - NMR

3odc, 3ode - hPARP 1 zinc finger 2 + DNA

2cs2 - hPARP 1 zinc finger 2 - NMR

2jvn – hPARP 1 domain C – NMR

2cr9 - hPARP 1 domain WGR – NMR

2rd6 - hPARP 1 + inhibitor

3l3l, 3l3m, 3gn7 – hPARP 1 (mutant) + inhibitor

2rcw - hPARP 1 α-helical and catalytic domain + inhibitor

3gjw – hPARP 1 α-helical and catalytic domain (mutant) + inhibitor

PARP 2
3kjd, 3kcz - hPARP 2 catalytic domain + inhibitor

3kjd - hPARP 2 catalytic domain + inhibitor

1gs0 - PARP 2 catalytic domain - mouse

PARP 10
3hkv - hPARP 10 catalytic domain (mutant) + inhibitor

2dhx - hPARP 10 RRM domain

PARP 11
2dk6 - hPARP 11 WWE domain – NMR

PARP 14
3goy - hPARP 14 catalytic domain + inhibitor

PARP 15
3blj - hPARP 15 catalytic domain

3gey - hPARP 15 catalytic domain + inhibitor

3kh6 – hPARP 15 macro domain 2 + nucleotide

PARP - chicken
1a26 – cPARP catalytic domain +carba-NAD – chicken

2paw - cPARP catalytic domain

2pax, 4pax, 3pax, 1pax, 1efy - cPARP catalytic domain + inhibitor

Tankyrases
2rf5 - hTank 1 catalytic domain (mutant)

3kr7 - hTank 2 catalytic domain

3kr8 - hTank 2 catalytic domain + inhibitor

3mhk, 3mhj, 3p0n, 3p0p, 3p0q - hTank 2 + inhibitor